Journal Articles

2021

Crisaborole prevents infiltration of neutrophils to suppress itch in a mouse model of atopic dermatitis
Sakai K, Sanders KM, Pavlenko D, Lozada T, Akiyama T. Itch. 2021 Apr;6(2):e53.

2020

IL-23 modulates histamine-evoked itch and responses of pruriceptors in mice
Pavlenko D, Funahashi H, Sakai K, Hashimoto T, Lozada T, Yosipovitch G, Akiyama T. Exp Dermatol. 2020 Dec;29(12):1209-1215.

Low-threshold mechanosensitive VGLUT3-lineage sensory neurons mediate spinal inhibition of itch by touch
Sakai K, Sanders KM, Lin SH, Pavlenko D, Funahashi H, Lozada T, Hao S, Chen CC, Akiyama T. J Neurosci. 2020 Sep 30;40(40):7688-7701

Protease-activated receptor-2 Regulates Neuro-epidermal Communication in Atopic Dermatitis
Buhl T, Ikoma A, Kempkes C, Cevikbas F, Sulk M, Buddenkotte J, Akiyama T, Crumrine D, Camerer E, Carstens E, Schön MP, Elias P, Coughlin SR, Steinhoff M. Frontiers in Immunology, 2020 Aug 12;11:1740

2019

Signal Transducer and Activator of Transcription 3 in Keratinocytes Regulates Histaminergic Itch but Not Nonhistaminergic Itch
Hashimoto T, Sakai K, Yosipovitch G, Akiyama T. Acta Derm Venereol. 2019 Sep 1;99(10):901-902.

A Subpopulation of Amygdala Neurons Mediates the Affective Component of Itch
Sanders KM, Sakai K, Henry TD, Hashimoto T, Akiyama T. J Neurosci. 2019 Apr 24;39(17):3345-3356.

Disinhibition of Touch-Evoked Itch in a Mouse Model of Psoriasis
Sakai K, Akiyama T. J Invest Dermatol. 2019 Jun;139(6):1407-1410.

Antipruritic Effects of Janus Kinase Inhibitor Tofacitinib in a Mouse Model of Psoriasis
Hashimoto T, Sakai K, Sanders KM, Yosipovitch G, Akiyama T. Acta Derm Venereol. 2019 Mar 1;99(3):298-303.

2018

Opposing effects of cervical spinal cold block on spinal itch and pain transmission Carstens E, Carstens MI, Akiyama T, Davoodi A, Nagamine M. Itch. 2018 Sep;3(3):e16.

Modulation of Itch by Localized Skin Warming and Cooling
Sanders KM, Hashimoto T, Sakai K, Akiyama T. Acta Derm Venereol. 2018 Oct 10;98(9):855-861.

Effects of Pruritogens and Algogens on Rostral Ventromedial Medullary ON and OFF Cells
Follansbee T, Akiyama T, Fujii M, Davoodi A, Nagamine M, Iodi Carstens M, Carstens E. J Neurophysiol. 2018 Nov 1;120(5):2156-2163.

Peripheral Gabapentin Regulates Mosquito Allergy-Induced Itch in Mice
Akiyama T, Andoh T, Ohtsuka E, Nojima H, Ouchi H, Takahata H, Kuraishi Y. Eur J Pharmacol. 2018 Aug 15;833:44-49.

2017

Role of Neurturin in Spontaneous Itch and Increased Nonpeptidergic Intraepidermal Fiber Density in a Mouse Model of Psoriasis
Sakai K, Sanders KM, Youssef MR, Yanushefski KM, Jensen LE, Yosipovitch G, Akiyama T. Pain. 2017 Nov;158(11):2196-2202.

Differing Intrinsic Biological Properties Between Forebrain and Spinal Oligodendroglial Lineage Cells
Horiuchi M, Suzuki-Horiuchi Y, Akiyama T, Itoh A, Pleasure D, Carstens E, Itoh T. J Neurochem. 2017 Aug;142(3):378-391.

Expression of Histidine Decarboxylase in the Epidermis of Primates With Chronic Itch
Inami Y, Nattkemper LA, Sakai K, Yosipovitch G, Akiyama T. Acta Derm Venereol. 2017 Jun 9;97(6):739-740.

Innocuous Warming Enhances Peripheral Serotonergic Itch Signaling and Evokes Enhanced Responses in Serotonin-Responsive Dorsal Horn Neurons in the Mouse
Akiyama T, Nagamine M, Davoodi A, Ivanov M, Carstens MI, Carstens E. J Neurophysiol. 2017 Jan 1;117(1):251-259.

2016

Mouse Model of Imiquimod-Induced Psoriatic Itch
Sakai K, Sanders KM, Youssef MR, Yanushefski KM, Jensen L, Yosipovitch G, Akiyama T. Pain. 2016 Nov;157(11):2536-2543.

Involvement of TRPV4 in Serotonin-Evoked Scratching
Akiyama T, Ivanov M, Nagamine M, Davoodi A, Carstens MI, Ikoma A, Cevikbas F, Kempkes C, Buddenkotte J, Steinhoff M, Carstens E. J Invest Dermatol. 2016 Jan;136(1):154-160.

Anatomical Evidence of Pruriceptive Trigeminothalamic and Trigeminoparabrachial Projection Neurons in Mice
Akiyama T, Curtis E, Nguyen T, Carstens MI, Carstens E. J Comp Neurol. 2016 Feb 1;524(2):244-56.

## publications (~2015)

Review Articles

New insights into the mechanisms behind mechanical itch
Sakai K, Akiyama T. Exp Dermatol. 2020 Aug;29(8):680-686.

Why Does Stress Aggravate Itch? A Possible Role of the Amygdala
Pavlenko D, Akiyama T. Exp Dermatol. 2019 Dec;28(12):1439-1441.

Alloknesis and Hyperknesis-Mechanisms, Assessment Methodology, and Clinical Implications of Itch Sensitization
Andersen HH, Akiyama T, Nattkemper LA, van Laarhoven A, Elberling J, Yosipovitch G, Arendt-Nielsen L. Pain. 2018 Jul;159(7):1185-1197.

The Vicious Cycle of Itch and Anxiety
Sanders KM, Akiyama T. Neurosci Biobehav Rev. 2018 Apr;87:17-26.

Central Mechanisms of Itch
Carstens E, Akiyama T. Curr Probl Dermatol. 2016;50:11-7.

Neural Processing of Itch
Akiyama T, Carstens E. Neuroscience. 2013 Oct 10;250:697-714.

Book

“Itch: Mechanisms and Treatment”, CRC Press. 2014 Akiyama T, and Carstens E. (Eds.)

Book Chapters

“Preclinical models of itch and pain” in “Itch and Pain: Similarities, Interactions, and Differences” Yosipovitch G, Andersen HH, and Arendt-Nielsen L (Eds). International Association for the Study of Pain (IASP) Press. 2020
Sanders KM, and Akiyama T.

“Serotonin receptors in pain and itch processing” in “Itch and Pain: Similarities, Interactions, and Differences” Yosipovitch G, Andersen HH, and Arendt-Nielsen L (Eds). International Association for the Study of Pain (IASP) Press. 2020
Kent S, Sanders KM, and Akiyama T.

“Alloknesis and hyperknesis: sensitization for itch” in “Hyperalgesia and Allodynia” Tsagareli M (Ed), Hauppauge, New York: Nova Science Publishers, Inc. 25-62, 2018
Sanders KM, and Akiyama T.

“Cutaneous Neurophysiology” in “4th edition Dermatology” Bolognia JL, Schaffer JV and Cerroni L (Eds), Elsevier 5: 1-11, 2017
Yosipovitch G, and Akiyama T.

“Central Mechanisms of Itch” in “Itch-Management in Clinical Practice” Szepietowski JC and Weisshaar E (Eds.), Karger 50:11-7, 2016
Akiyama T, and Carstens E.

“Neural Processing of Itch” in “Pruritus, Second Edition” Laurent Misery and Sonja Stander (Eds.), Springer 3-11, 2016
Akiyama T, and Carstens E.

“Protease-activated receptors and itch” in “Handbook of Experimental Pharmacology-Pharmacology of Itch” Cowan A and Yosipovitch G. (Eds.), Springer 226:219-235, 2015
Akiyama T, Lerner EA, and Carstens E.

“Spinal processing of itch and pain” in “Recent evidence of itch and pain” Yasushi Kuraishi (Eds.) in Japanese, Shinko Trading Company Ltd., Publication Department of Medical Books. Pain Clinic. 34(4): 493-504, 2013
Akiyama T

“Assessment of chemically-evoked itch in rodents” in “Pain Models: Translational Relevance and Applications” Hermann O Handwerker (Eds.), IASP press 403-414, 2013
Akiyama T, and Carstens E.